COPD all in one

Box Chart P6

NI00 IMS a web

COPD

COPD

Metabolites related to COPD

Within a clinical study the exhaled breath of persons suffering COPD without and with lung cancer and healthy volunteers was investigated using an Ion Mobility Spectrometer coupled to a Multi-Capillary Column without any pre-separation or pre-enrichment. A single analyte was be able to separate the two groups of healthy persons and those such suffering from COPD with and without lung cancer. The sensitivity obtained was 60%, the specificity 91%, the positive predictive value 95%. The peak was characterized as cyclohexanone (CAS 108-94-1). Thus, a concentration of cyclohexanone above the threshold could be seen as an indicator for COPD. Within 2013 a decision tree modell was formed including the VOCs PA 8, Ammonia, 2-Ethyl-1-Hexanol and PA 12 were in total 92 (97 %) of the patients suffering COPD and 23 of the healthy controls (65 %) are classified correctly. The identity of the peak used for separation of the two groups must be validated with a greater population and external standards. Additional studies with a higher population and parallel measurements using GC/MSD will support the identification further. 

Publications

  • Besa, Vasiliki; Teschler, Helmut; Kurth, Isabella; Khan, Amir Maqbul; Zarogoulidis, Paul; Baumbach, Joerg Ingo; Sommerwerck, Urte; Freitag, Lutz; Darwiche, Kaid;Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjectsInternational Journal of Chronic Obstructive Pulmonary Disease 10, (2015) 399-406http://dx.doi.org/10.2147/COPD.S76212
  • Westhoff, M.; Litterst, P.; Maddula, S.; Bödeker, B.; Baumbach, J.I.;Statistical and bioinformatical methods to differentiate chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control by breath analysis using ion mobility spectrometrInt. J. Ion Mobility Spectrom. 11, 4 (2011) 139-14910.1007/s12127-011-0081-x
  • Koczulla, R.; Hattesohl, A.; Schmid, S.; Bödeker, B.; Maddula, S.; Baumbach, J.I.;MCC/IMS as potential noninvasive technique in the diagnosis of patients with COPD with and without alpha 1-antitrypsin deficiencyInt. J. Ion Mobility Spectrom. 14, 4 (2011) 177-185
  • Westhoff, M.; Litterst, P.; Maddula, S.; Bödecker, B.; Rahmann, S.; Davies, A.N.; Baumbach, J.I.;Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometryInt. J. Ion Mobility Spectrom. 13, 3-4 (2010) 131-139