Propofol Ref neg high

Anaesthesie Monitoring

Detection of chemicals used in anaesthetics

In human breath signals of chemicals used in anaesthetics are detectable directly. E.g. propofol could be determined and quantified in human breath. Direct correlations were found between the concentration values in breath and such in blood. In addition, correlations with the BIS value are found. Within 2013 a IMS version was introduced, able to deliver a Propofol-value each minute. 


  • Kreuer, S.; Hauschild, A.-C.; Fink, T.; Baumbach, J.I.; Maddula, S.; Volk, Th.;Two different approaches for pharmacokinetic modeling of exhaled drug concentrationsnature Scientific Reports 5423, (2014) 1-610.1038/srep05423
  • Buchinger, H.; Kreuer, S.; Hellbrück, R.; Wolf, A.; Fink, T.; Volk, Th.; Bödeker, B.; Maddula, S.; Baumbach, J.I.;Minimal retarded Propofol signals in human breath using ion mobility spectrometryInt. J. Ion Mobility Spectrom. 16, 3 (2013) 185-190
  • Kreuder, A.-E.; Buchinger, H.; Kreuer, S.; Volk, Th.; Maddula, S.; Baumbach, J.I.;Characterization of propofol in human breath of patients undergoing anesthesiaInt. J. Ion Mobility Spectrom. 14, 4 (2011) 167-17510.1007/s12127-011-0080-y
  • Perl, T.; Carstens, E.T.H.; Hirn, A.; Quintel, M.; Baumbach, J.I.; Nolte, J.; Jünger, M.; Vautz, W.;Propofol in der Atemluft – MCC-Ionen Mobilitäts SpektrometrieBiomedizinische Technik 55, Suppl. 1 (2010)DOI 10.1515/BMT.2010.533
  • Maurer, F.; Lorenz, D.J.; Pielsticker, G.; Volk, T.; Sessler, D.I.; Baumbach, J.I.; Kreuer, S.;Adherence of volatile propofol to various types of plastic tubingJournal of Breath Research 11, 1 (2017) 01600910.1088/1752-7163/aa567e
  • Maurer, F.; Walter, L.; Geiger, M.; Baumbach, J.I.; Sessler, D.I.; Volk, T.; Kreuer, S.;Calibration and validation of a MCC/IMS prototype for exhaledpropofol online measurementJournal of Pharmaceutical and Biomedical Analysis 145, (2017) 293–29710.1016/j.jpba.2017.06.052